Catalina de Salazar was born about 1615 in Santa Fe, Kingdom of Nuevo Mexico. She was christened about 1615 in Santa Fe, Kingdom of Nuevo Mexico. Catalina was a widow by 1663. At this time we learn that Luis had been the Alcalde Mayor and Captain of the Tewa jurisdiction. Catalina was very likely a daughter of Captain Sebastain Rodriques de Salazar. She died after 1662 in Santa Cruz de la Canada, Kingdom of Nuevo Mexico. She was buried after 1662 in Santa Cruz de la Canada, Kingdom of Nuevo Mexico.

Catalina de Salazar was born before July 17, 1617, the first event for which there is a recorded date.

She married twice. She married Luis Martín Serrano I and Pedro Hurtado Zacatecas of Mexico (on July 17, 1617). Catalina and Pedro became the parents of Andres Hurtado in Durango, Mexico circa 1628.