Ephraim's wife was named Betty (Elizabeth). Some oral histories (e.g. Osbornes of Harlan Co., KY) say she was a Howard. She is not Elizabeth WELLS Howard. The Elizabeth Howard who married a Wells and is mentioned in Joshua Howard's will is documented to have stayed married to Mr. Wells in Maryland having many children there and never went to North Carolina.

Ephraim and Betty's documented children are Robert Osborne m. Ann (see below); Solomon Osborne (killed by Indians while hunting, 1764) m. Nancy Davidson; Enoch Osborne m. Jane Hash (see above); Jonathan Osborne m. (1) Nancy Howell, (2) Agnes Wells and (3) Mary; Ephraim Osborne (Jr.) (see below) m. Mary Brock (daughter of Aaron Brock [aka Cutsawah or Red Bird] and a Cherokee mother) - died in Harlan Co., KY. There may have daughters, but there is little documentation. The ones proposed are Ellender Osborne m. William Hash; Nancy Osborne m. George Livesay; and Chloe Osborne m. George Howard. It is thought that Ephraim's children were born between 1743 and 1765.

The Clinch River Valley line originates with Caleb Osborne m. Hannah (Howard?). He is suspected to be the brother of this Ephraim Osborne as they appear together in Rowan Co., NC (Rita Sutton). -------------------- Not Elizabeth WELLS Howard.