Do not confuse her with her mother, who was also named Iotapa. The Loeb Family Tree and other sources erroneously say Iotapa II was Priestess-Queen of Emesa, and married Sampsigeratnus II. In fact, this Iotapa was a granddaughter of Sampsigeratnus II. She had no known issue.
She was a deaf-mute.
The two daughters of Aristobulus (Mariamne and Herodias) both married kings (brothers Herod Archelaus and Herod Antipas, respectively). Two of the three sons of Aristobulus became kings (Herod Agrippa and Herod ben Aristobulus) Herod Agrippa become king of the Jews under Caligula ruling, for a short time, all the lands of his grandfather Herod. His brother Herod became king of Chalcis. As to the third brother, Aristobulus, we know very little. Below are the quotes from Josephus about the third son of Aristobulus IV:
Aristobulus, the third brother of Agrippa, married Jotape, the daughter of Sampsigeramus, king of Emesa; they had a daughter who was deaf, whose name also was Jotape. Antiquities, Book XVIII 5:4.
Hereupon Flaccus received [Agrippa] kindly, and he lived with him. Flaccus had also with him there Aristobulus, who was indeed Agrippa's brother, but was at variance with him; yet did not their enmity to one another hinder the friendship of Flaccus to them both, but still they were honorably treated by him. However, Aristobulus did not abate of his ill-will to Agrippa, till at length he brought him into ill terms with Flaccus; the occasion of bringing on which estrangement was this: [Aristobulus found out Agrippa took a bribe and reported him for it to the Roman authorities]. Antiquities, Book XVII 6:3.
Now after this, Herod the king of Chalcis died, and left behind him two sons, born to him of his brother's daughter Bernice; their names were Bernie Janus and Hyrcanus. [He also left behind him] Aristobulus, whom he had by his former wife Mariamne. There was besides another brother of his that died a private person, his name was also Aristobulus, who left behind him a daughter, whose name was Jotape: and these, as I have formerly said, were the children of Aristobulus the son of Herod." Jewish Wars, Book II 11:6.
To sum up, Aristobulus V (or Aristobulus ben Aristobulus) married Jotape, had a deaf daughter also named Jotape, died a private man (i.e., wasn't given a kingdom), and had a serious falling out with his brother Agrippa.
Herod the Great had two daughters by Mariamne, the [grand] daughter of Hyrcanus; the one was Salampsio, who was married to Phasaelus, her first cousin, who was himself the son of Phasaelus, Herod's brother, her father making the match; the other was Cypros, who was herself married also to her first cousin Antipater, the son of Salome, Herod's sister. Phasaelus had five children by Salampsio; Antipater, Herod, and Alexander, and two daughters, Alexandra and Cypros; which last Agrippa, the son of Aristobulus, married; and Timius of Cyprus married Alexandra; he was a man of note, but had by her no children. Agrippa had by Cypros two sons and three daughters, which daughters were named Bernice, Mariarune, and Drusius; but the names of the sons were Agrippa and Drusus, of which Drusus died before he came to the years of puberty; but their father, Agrippa, was brought up with his other brethren, Herod and Aristobulus, for these were also the sons of the son of Herod the Great by Bernice; but Bernice was the daughter of Costobarus and of Salome, who was Herod's sister. Aristobulus left these infants when he was slain by his father, together with his brother Alexander, as we have already related. But when they were arrived at years of puberty, this Herod, the brother of Agrippa, married Mariamne, the daughter of Olympias, who was the daughter of Herod the king, and of Joseph, the son of Joseph, who was brother to Herod the king, and had by her a son, Aristobulus; but Aristobulus, the third brother of Agrippa, married Jotape, the daughter of Sampsigeramus, king of Emesa; they had a daughter who was deaf, whose name also was Jotape; and these hitherto were the children of the male line.
Josephus: Antiquities of the Jews XVIII Chapter 5 .http://religiousstudies.uncc.edu/people/jtabor/john.html