Jan Stanisław Sapieha (Lithuanian: Jonas Stanislovas Sapiega) (1589–1635) was a Polish-Lithuanian noble, starost of Słonim, Court Marshal of Lithuania from 1617, Great Lithuanian Marshal from 1621.

Son of Lew Sapieha. Studied abroad. Friend and supporter of prince and later king Władysław IV Waza. Deputy to many Sejms, took part in the Polish-Swedish wars, but gained a reputation as a weak tactician, suffering several defeats. Near the end of his life had mental health problems, but his friend the king allowed him to remain at the royal court till his last days.

Chancellor of Lithuania from 1621-1635. His father had been the most powerful man of his time and he himself had risen to the highest civil position. But his sons by each of his wives died in childhood and he left no children. More, because his mental health was not good towards the end of his life and he survived his father by only two years, his father had made arrangements for the securing of the properties. If Jan died or was incompacitated, the property would go to his brother Kazimierz. If Kazimierz died, it would pass to the line of Lev Sapieha's father's brother's descendants. Kazimeirz survived Jan, but in the end, the estate moved to the cousin line as Lev Sapieha had foreseen.