Admitted to the musicians guild in Antwerp, Belgium, in 1557. Musician in the court string consort 1563 - 1616.

Joseph, turns up in British State papers beginning in 1563, was living in Blackfriars, London in 1571, and listed as a Venetian on a return of Strangers dated that year

Joseph and Peter were two of four Lupos listed among the six violinists who played at the funeral of Queen Elizabeth in 1603

The augmentation and crest granted to the Lupos contains four Tudor roses (i.e. white over red), signifying service under Henry, Edward, Mary and Elizabeth and is a testement to their long years of service to the English royal family. This service extended into the Stuart dynasty, in the personages of Joseph's sons Thomas, Sr. and Horatio, and Peter's son Thomas, Jr.