On 10 August 1680, the family was forced to leave their home due to the Pueblo Revolt. They retreated into Santa Fe, where the Pueblos then laid siege to the town. Meanwhile the Indians destroyed the family’s Las Barrancas hacienda. Three days later Andres is killed by Indians and Juana and the children manage to escape to Guadalupe del Norte (El Paso).

Juana and her children re-entered New Mexico, but they could not return to their destroyed home at Las Barrancas. Apache raids prevented Spanish resettlement of this area.