Khadijah bint Khuwaylid was the first wife of Muhammad and the first person to accept Islam. She is revered amongst Muslims as a "mother of the believers".

The daughter of a wealthy merchant and later a successful businesswoman in her own right, she and Muhammad shared a monogamous relationship until her death in 619 or 623 (accounts differ). She fathered two sons: Qasim and Abdullah (better known by his nicknames Tahir and Tayyib); and four daughters: Zainab, Ruqayyah, Umm Kulthum and Fatimah. There is a dispute over the paternity of Khadijah's daughters, as Shia scholars view the first three of them as the daughters from previous marriages and Fatimah alone as the daughter of Muhammad.

The Prophet Muhammad never stopped loving Khadijah, and although he married several more wives in later years and loved them all, it is clear that Khadijah always had a special place in his heart. Once Aisha, his third wife, asked him if Khadijah had been the only woman worthy of his love. Muhammad replied:

"She believed in me when no one else did; she accepted Islam when people rejected me; and she helped and comforted me when there was no one else to lend me a helping hand."

Wikipedia: http://en.wikipedia.org/wiki/Khadija

Ummah.net: http://www.ummah.net/khoei/khadija.htm

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Rasulullah menikahi Siti Khadijah ketika berumur 25 tahun, sedangkan Siti Khadijah sendiri sudah berumur 40 tahun. Khadijah sebelumnya sudah menikah 2 kali, suami pertama Khadijah adalah Aby Haleh Al Tamimy dan suami keduanya adalah Oteaq Almakzomy, keduanya sudah meninggal sehingga menyebabkan Khadijah menjadi janda.

Lima belas tahun setelah menikah dengan Siti Khadijah, Muhammad SAW pun diangkat menjadi Rasul, yaitu pada umur 40 tahun. Siti Khadijah meninggal dunia pada tahun 621, dimana tahun itu bertepatan dengan Mi’raj nya Nabi Muhammad SAW ke Surga. Rasulullah sangatlah mencintai Khadijah, sehingga hanya setelah sepeninggal Siti Khadijah lah Rasulullah baru mau menikahi dengan wanita lain.

Rumah tangga Rasulullah dengan Siti Khadijah adalah rumah tangga yang luar biasa. Ada 6 anak yang lahir dari rahim Siti Khadijah, yaitu bernama Al Qasim (meninggal semasa berumur 2 th), Abdullah (meninggal semasa bayi), Zainab, Ruqaiyah, Ummu Kalthun, Fatimah. Sebelumnya Siti Khadijah telah punya 2 anak, namun tidak ada iri diantara mereka.

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Source 1: http://en.wikipedia.org/wiki/Khadijah_bint_Khuwaylid

Source 2: http://www.islamswomen.com/articles/khadijah_bint_khuwaylid.php