William Reynolds settled in Providence, RI. He and others paid two shillings six pence apiece for ground that had been granted to them. About August 20, 1637, he and twelve others signed a compact that reads: "We whose names are hereunder, desirous to inhabit in the town of Providence, do promise to subject our self in active and passive obedience to all such orders or agreements as shall be made for public good or the body in an orderly way, by the major consent of the present inhabitants, masters of families, incorporated together in Town fellowship, and others whom they admit unto them only in civil things."

He was one of thirty nine who signed an agreement for a form of government on July 27, 1640. On November 17, 1641, he with twelve others complained in a letter to Massachusetts of the "insolent and riotous carriage of Samuel Gorton and his company," and therefore the petitioners desired Massachusetts to "lend us a neighbor like helping hands," etc. On January 30, 1644, he was one of the Providence settlers who testified as to the outrage on Warwick settlers by Massachusetts.

On January 27, 1645, he sold to Robert Williams all his houses and home share and three small pieces of meadow, and on the same date he sold to William field a share of six acres on Fox's Hill. On April 27, 1646, he sold to Thomas Lawton his valley of eighty acres, and three acres of meadows.

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After leaving England, William Reynolds settled in Bermuda.