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I would like to gather everyone on Geni with PORPHYRIA, so we can check if we're related.

Do you or anyone in your family suffer from Porphyria? Please join, Thank you!

What is Porphyria? http://en.wikipedia.org/wiki/Porphyria

Known Porphyria Ancestry:

The genealogical studies of Dean and Barnes suggested that the gene for the South African form of variegate porphyria was introduced into South Africa in 1688, when two Dutch settlers, Gerrit Jansz van Deventer and Adriaantje Ariens married in Cape Town.

This has now been proven: most South African patients carry a single founder mutation, and haplotype analysis of the ancestral chromosomes has confirmed a relationship with Dutch families with variegate porphyria. In the years following 1688 the gene spread widely through the South African population and is common amongst South Africans of Dutch ancestry, whatever their race or home language.

http://www.porphyria.uct.ac.za/professional/prof-vp.htm

Variegata porphyria (VP) is caused by mutations in the gene for another enzyme in the haem production pathway. The term variegate describes the variable nature of the symptoms; most people do not experience any symptoms while others show a similar condition to that seen in AIP, with abdominal pains, skin rashes, and psychosis in addition to some photosensitivity.

King George III, often called the mad king, is suspected of suffering from VP. Between 1788 and 1804, he suffered bouts of ‘‘madness’’ involving a rapid pulse, fever, abdominal pains, constipation, cramp, skin blistering, “port-wine-coloured” urine, and rambling speech degenerating into obscenities and hallucinations.

Just as each episode was acute in onset, the recovery phase was equally sudden and rapid. His disease can be traced back to his ancestors, Mary Queen of Scots in the 1500s, and her son, King James I, whose physician noted urine ‘‘red like Alicante wine’’.

Other notable royal sufferers are said to include James I’s son Henry, Prince of Wales who had a similar illness and died suddenly, with allegations that he had been poisoned, the Duchess of Orleans who died of a sudden episode of excruciating abdominal pain, Queen Anne, George IV, and Princess Charlotte who died suddenly after childbirth.

Prince William of Gloucester (the current duke’s elder brother, who was killed in a plane crash in 1972) had been diagnosed with porphyria suggesting the presence of a gene defect in the family and though it is possible that Queen Victoria may have also carried the gene, no symptoms were reported.

Do you or anyone in your family suffer from Porphyria, please join, Thank you!