The Spanish Inquisition (Spanish: Inquisición española), officially known as the Tribunal of the Holy Office of the Inquisition (Tribunal del Santo Oficio de la Inquisición), was a tribunal established in 1480 by Catholic Monarchs Isabella I of Castile. It was intended to maintain Catholic orthodoxy in their kingdoms, and to replace the Medieval Inquisition which was under Papal control. The Inquisition was originally intended in large part to ensure the orthodoxy of those who converted from Judaism and Islam. This regulation of the faith of the newly converted was intensified after the royal decrees issued in 1492 and 1501 ordering Jews and Muslims to convert or leave.

List of Spanish Grand Inquisitors

• 1483-1498 : Tomás de Torquemada, Prior of Santa Cruz
• 1498-1507 : Diego de Deza Tavera, Archbishop of Seville
• 1506-1507 : Diego Ramírez de Guzmán, Bishop of Catania and Lugo
• 1507-1517 : Francisco Jiménez de Cisneros, Cardinal and Archbishop of Toledo
• 1507-1513 : Juan Enguera, Bishop of Vich
• 1512-1516 : Luis Mercader, Bishop of Tortosa
• 1516-1523 : Adriaan Floriszoon Boeyens, Cardinal and Bishop of Tortosa and Pope Adriano VI
• 1523-1538 : Alonso Manrique de Lara, Cardinal and Archbishop of Seville
• 1539-1545 : Juan Pardo de Tavera, Archbishop of Toledo
• 1546 : Juan García de Loaysa y Mendoza , Archbishop of Seville
• 1547-1566 : Fernando de Valdés, Archbishop of Seville
• 1567-1572 : Diego de Espinosa, Bishop of Sigüenza
• 1572 : Pedro Ponce de León, Bishop of Ciudad Rodrigo
• 1573-1594 : Gaspar de Quiroga, Cardinal and Archbishop of Toledo.
• 1595 : Jerónimo Manrique de Lara, Bishop of Ávila
• 1596-1599 : Pedro de Portocarrero, Bishop of Calahorra and Cuenca
• 1599-1600 : Fernando Niño de Guevara, Cardinal and Archbishop of Seville
• 1602 : Juan de Zúñiga, Bishop of Cartagena
• 1603-1608 : Juan Bautista de Acevedo, Bishop of Valladolid and Patriarch of the Indias
• 1608-1618 : Bernardo de Sandoval y Rojas, Cardinal and Archbishop of Toledo
• 1619-1621 : Luis de Aliaga Martínez, Royal Confessor
• 1622-1626 : Andrés Pacheco, Bishop of Cuenca and Patriarch of the Indias
• 1627-1632 : Antonio de Zapata y Cisneros, Cardinal and Archbishop of Burgos
• 1632-1643 : Antonio de Sotomayor, Archbishop of Damascus
• 1643-1665 : Diego de Arce y Reinoso, Bishop of Palencia
• 1665 : Pascual de Aragón, Archbishop of Toledo
• 1666-1669 : Juan Everardo Nithard, Confessor to the King, Cardinal and Archbishop of Edessa
• 1669-1695 : Diego Sarmiento de Valladares, Bishop of Plasencia
• 1695-1699 : Juan Tomás de Rocaberti, Archbishop of Valencia
• 1699 : Alonso de Aguilar, Cardinal
• 1699-1705 : Baltasar de Mendoza y Sandoval, Bishop of Segovia
• 1705-1709 : Vidal Marín del Campo, Bishop of Ceuta
• 1709-1710 : Antonio Ibáñez de la Riva Herrera, Archbishop of Zaragoza
• 1711-1716 : Francisco Giudice, Cardinal
• 1717 : José de Molines, Auditor of the Roman Rota
• 1720 : Juan de Arzamendi
• 1720 : Diego de Astorga y Céspedes, Archbishop of Toledo
• 1720-1733 : Juan de Camargo y Angulo y Pasquer, Bishop of Pamplona
• 1733-1740 : Andrés de Orbe y Larreátegui, Archbishop of Valencia
• 1742-1746 : Manuel Isidro Orozco Manrique de Lara, Srchbishop of Santiago
• 1746-1755 : Francisco Pérez de Prado y Cuesta, Bishop of Teruel
• 1755-1774 : Manuel Quintano Bonifaz, Archbishop of Farsalia
• 1775-1783 : Felipe Beltrán Serrano, Bishop of Salamanca
• 1784-1793 : Agustín Rubin de Ceballos, Bishop of Jaén
• 1793-1794 : Manuel Abad y Lasierra, Archbishop of Selimbria
• 1794-1797 : Francisco Antonio Lorenzana, Cardinal and Archbishop of Toledo
• 1798-1808 : Ramón José de Arce, Archbishop of Burgos and Zaragoza
• 1814-1818 : Francisco J. Mier y Campillo, Aishop of Almería
• 1818-1820 : Jerónimo Castillón y Salas, Bishop of Tarazona