Tori Amos has said in interviews that she had two maternal second-great-grandparents who were enrolled Eastern Cherokee. Genealogists have never been able to find the records, but since her statements are more specific than the usual, I thought it was worth pursuing.
I've now gone through all 16 of her second-great-grandparents, and I've found that her ancestry is European. There are a couple points worth double-checking, however:
1) Anderson Jackson Copeland -- his wife and son are listed as white, so that makes it improbable for him to be Cherokee
2) John Akins and Sallie Akins -- as with Jack (above), their son is listed as white, so once again improbable
If anyone is interested in pursuing this, those would be the only points to check; the other 13 are very clearly white. If not, we can assume her family story was inaccurate.
Here's what Ethnicelebs has to say, which matches what I found. For Margaret Loraine Rice, she's listed as white on the 1880 and 1900 U.S. Federal Censuses.
----
"The first of Tori's great-great-grandparents cited as Cherokee was a woman named Margaret Loraine Little. Margaret is listed as 'White' on United States Censuses. Margaret's mother's name is sometimes cited as Elizabeth J. McAllister.
The second of Tori's great-great-grandparents cited as Cherokee was a man named John Akins. John’s son, Tori's great-grandfather, John Calhoun Akins, is listed as 'White' on United States Censuses."
There's this, from https://www.ncpedia.org/amos-tori:
"Amos had a close relationship with her maternal grandfather, Calvin Copeland, a member of the Eastern Cherokee Nation."
I cant find Calvin Clinton Copeland in the rolls, but maybe someone else can.