My info is that this John Isaac / Oowanee Vann was the son of John Vann and Agnes Weatherford, based on info on Ancestry trees that show:
John Isaac Vann
BIRTH: 1761 Georgia, United States
DEATH: Abt 1863 Bristow, Creek Co., Oklahoma
sources (2)records (1)
Family Info
Father
John Joseph "U-Wa-Ni" VANN (CHEROKEE) Interpreter** (1735–1815)
Mother
Agnes Ruth WEATHERFORD (FULL CREEK) (1745–1819)