I just found this site that lists Alexander McDonald and wife Hannah Kirkpatrick:
https://www.angelfire.com/al2/McCalebs/Alexander_McDonald.htm
Desc. of Alexander McDONALD, II by Alan Vance McDONALD
1. Alexander McDonald II b. 25 Jul 1768, Beverly Manor, Orange County, Va, (son of Alexander McDonald I and Margaret Randolf/Harrison) m. 11 Oct 1798, in Jefferson Cnty, Tenn, Hannah Kirkpatrick, b. 6 Mar 1779, Watauga Cnty, N.C., d. JUN 1857, Green County, TN. Alexander died 5 Sep 1834, Whitesburg, Jefferson Cnty, TN.
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It has his parents as Alexander McDonald I and wife Margaret but they're not the same Alexander and Margaret connected here on Geni.
They are listed on Wiki:
https://www.wikitree.com/wiki/McDonald-7388
and Margaret's maiden name shows as Harrison
There are a number of descendants whose DNA results are noted on the righthand side of the Wiki page.