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Rabbi Isaac became Rabbi around 1820 or according to others around 1830 and was the first Rabbi there.
http://wikigenia.org.il/index.php?title=%D7%91%D7%95%D7%A8%D7%A9%D7%94
https://tablet.otzar.org/pages/?&restore=1&t=1589109717302&pagenum=...
http://www.yad.org.il/petah-tikva/show_item.asp?levelId=15371&itemI...
It seems he was appointed through his brother-in-law Rabbi Menachem Mendel Stern,, and according to Yakatuel Grunwald 'מצבת קודש' זיכרון לראשונים-סיגעט they were married to two sisters. (and it would seem that he had two wives, or the theory isn't right -since he brings no evidence)
אייזיק, החל לכהן בשנת 1820 לערך והיה הרב הראשון בעיירה http://wikigenia.org.il/index.php?title=%D7%91%D7%95%D7%A8%D7%A9%D7%94