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The Pazzi conspiracy (Italian: Congiura dei Pazzi) was a plot by members of the Pazzi family and others to displace the Medici family as rulers of Renaissance Florence.

On 26 April 1478 there was an attempt to assassinate Lorenzo de' Medici and his brother Giuliano. Lorenzo was wounded but survived; Giuliano was killed. The failure of the plot served to strengthen the position of the Medici. The Pazzi were banished from Florence.

https://en.wikipedia.org/wiki/Pazzi_conspiracy

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Conspiracy Family Scheme

Pope Sixtus IV is Francesco de'Pazzi's sister-in-law's niece's fiancé's wife's husband's uncle!

Francesco de'Pazzi Guglielmo de'Pazzi his brother → Bianca de' Medici his wife → Lorenzo de' Medici, il Magnifico her brother → Luisa de' Medici his daughter → Giovanni de'Medici, il Popolano her fiancé → Caterina Sforza, contessa di Forli his wife → Girolamo Riario, signore di Imola e Forli her husband → Bianca della Rovere his mother → Pope Sixtus IV her brother