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- Cornelis Jacobsz Drebbel (1572-1633) - Built the first navigable submarine (1620)
- Gemma Frisius (1508-1555) - applied his mathematical expertise to geography, astronomy and map making. became the leading theoretical mathematician in the Low Countries.
- Nicolaas Hartsoeker (1656-1725) invented the screw-barrel simple microscope
- Jan van der Heyden (1637-1712) - he significantly contributed to contemporary firefighting
- Romeyn de Hooghe (1645-1708) - invented a way to print on cotton
- Christiaan Huygens (1629-1695)
- Constantyn Huygens (1628-1697)
- Zacharias Jansen (1585-1632) - invented the first optical telescope
- Jan Adriaanszoon Leeghwater (1575-1650)
- Antoni van Leeuwenhoek (1632-1723)
- Johannes Lippershey (1570-1619)
- Gerardus Mercator (1512-1594)
- Adriaan Metius (1571-1635)
- Johan Joosten van Musschenbroeck (1660-1707)
- Willebrord Snel van Royen (1580-1626)
- Cornelis Cornelisz van Uitgeest (1550-1607)
- Andreas Vesalius (1514-1564) - founder of modern human anatomy
- Ferdinand Verbiest (1623-1688) - corrected the Chinese calendar, designed the first steam car and a thermometer