When you say noteworthy guests, do you mean the ones noteworthy for having been on like 10+ times? I feel like people like Brian Williams and Denis Leary basically are part of the show now, so if that's what you mean, I say keep.
If you mean "random starlet who appeared once," I don't think that belongs in any project -- are we going to do that for every chat show? -- but if someone wants to build and maintain it, more power to them.