Didn't find much that is relevant, just one genealogist claiming she has two sisters in addition to her brother, John Whittington https://ancestors.familysearch.org/en/L8M3-K7B/sir-william-whitting...
On Geni she is born after her father's death.
And her 'child'(?) Sir William de Lyttleton, of Frankley is born before her own birth date.
I find her husband here https://www.wikitree.com/wiki/Littleton-61#:~:text=Sir%20William%20....
And here, where his wife is not identified and it only states that he was succeeded by his son, John Lyttleton, ca. 1500 - 1533: https://en.wikipedia.org/wiki/Lyttelton_family#Early_members John Littleton
The Wikipedia source included on the About for her husband Sir William de Lyttleton, of Frankley is relevant only to later generations, so is of no help with this particular family group.
The other links have only a little more information, which conflict with one another:
https://our-royal-titled-noble-and-commoner-ancestors.com/p510.htm#...
http://www.thepeerage.com/p24286.htm#i242857
This is the irrelevant Wikipedia source linked on her husband's About. That information doesn't directly reveal anything about their particular family group.
http://en.wikipedia.org/wiki/Baron_Lyttelton