Unknown (de Sacerdotibus) Castellazzo - Contemplation

I wonder whether the fact that a daughter of Abram Saceerdotibus married a son of R' Abraham Sachs (an Ashkenazi) implies anything about the origins of the Sacerdotibus family? The earliest reference I have found to the Sacerdotibus family in the Duchy of Milan is from 1485 (see document under Abramo). Later on, after the Phillip II of Spain becomes ruler of Duchy of Milan, both Abramo's son Vitale and grandson Simone become diplomatic agents for Phillip II, and Simone became involved with the immigration process for Sephardim to Piedmont, but does this imply that the family was originally from Aragon or elsewhere in Spain? This is still an active investigation so I appreciate any fact which can be shared on the origins of the Sacerdotibus family.