wife, Betzalel ., [Maharal's mother]

Mrs. Betzalel Ben Chaim, mother of the Maharal, was possibly the daughter of Rabbi Chaim ISSEMHEIMER. See recent scholarship at https://tinyurl.com/stjl3oq.

They had four sons and three daughters - Tha Maharal was their youngest son:

1. daughter

2. Rabbi Chaim ben Betzalel (b. 1506? 1510? Worms, d. 1588, Rabbi of Friedberg).

3. Sinai (b. ca 1508 Worms, d. 1607 Kolin).

4. Rabbi Shimshon (Samson) ben Bezalel (b. 1522? 1510? Prague, d. Kremitz),

5. daughter married Zecharia Mendle KLOIZNER the Elder.

6. daughter married R. Avigdor KARA

7. The youngest son was the Maharal of Prague, Rabbi Judah (Yehuda) Liwa ben Betzalel (b. 1525 Posen or Pesach Eve. 1512 Worms, d. 22 August 1609 Prague, or 17 September 1609

Rabbi Betzalel married the daughter of Rabbi Chaim ISSEMHEIMER or married daughter of Rabbi Yitzchak KLOBER of Worms.