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Spanish Portuguese French German English and Welsh: from the personal name Manuel a short form of Emanuel . Compare Manwill . Catalan and Spanish: possibly also a habitational name from Manuel in Valencia province. Americanized form of any of various other European surnames derived from Emanuel for example the Greek and Serbian patronymics Manouilidis and Manojlović (see Manojlovic ) respectively.
Source: Dictionary of American Family Names 2nd edition, 2022