María Enríquez de Quiñones

In 1448, the Duke married María Enríquez de Quiñones y Toledo, daughter of Fadrique Enríquez, with whom he had 5 sons and 4 daughters. A granddaughter, María de Toledo y Rojas, married Diego Colón, son of Christopher Columbus.

By María Enríquez:

Fadrique Álvarez de Toledo, 2nd Duke of Alba (1460–1531) Mencia de Toledo, married Beltrán de la Cueva, 1st Duke of Alburquerque Teresa de Toledo, married Pedro Fernández Manrique, 2nd Count de Osorno Francisca de Toledo, married Francisco Fernández de la Cueva, 2nd Duke of Alburquerque María de Toledo, married Gómez Suárez de Figueroa, 2nd Count of Feria Gutierre de Toledo, Bishop of Plasencia García Álvarez de Toledo, 1st Lord of la Orcaiada Pedro de Toledo, 1st Lord of Mancera Fernando de Toledo, 1st Lord of las Villorias