wife, Yitzhak? Karo

http://www.jewishgen.org/rabbinic/journal/descent.htm

Sefer Toledot Ve-Niflaot Maharal (The Book of History and Wonders of the Maharal), by Meir Perles (Bilgoraj, 1911), has a footnote to the genealogy of Judah Loew, the Elder, of Prague (died in 1440), the great-great-grandfather of the MaHaRaL of Prague (Judah Loew, ben Bezalel, 1525–1609). It says: “The son of Judah's sister was the gaon (religious authority), Avigdor Karo ABD (av bet din, i.e., chief judge), Prague, uncle of Joseph Karo, author of Beit Yosef (Joseph's House) (of which Shulchan Aruch was an abbreviated version), and father of the gaon Judah Karo ABD Glogau, father of the gaon Joseph Karo who was ABD in 20 communities....”