- Edward James Olmos: Admiral William Adama / ... (73 episodes, 2004-2009)
- Mary McDonnell ... President Laura Roslin / ... (73 episodes, 2004-2009)
- Jamie Bamber ... Cpt. Lee 'Apollo' Adama / ... (73 episodes, 2004-2009)
- James Callis ... Dr. Gaius Baltar / ... (73 episodes, 2004-2009)
- Tricia Helfer ... Number Six / ... (73 episodes, 2004-2009)
- Grace Park ... Lt. Sharon 'Boomer' Valerii / ... (73 episodes, 2004-2009)
- Katee Sackhoff: Captain Kara 'Starbuck' Thrace / ... (71 episodes, 2004-2009)
- Michael Hogan ... Colonel Saul Tigh (69 episodes, 2004-2009)
- Aaron Douglas ... Chief Galen Tyrol (66 episodes, 2004-2009)
- Tahmoh Penikett ... Captain Karl 'Helo' Agathon / ... (64 episodes, 2004-2009)
- Alessandro Juliani ... Lt. Felix Gaeta (59 episodes, 2004-2009)
- Kandyse McClure ... Officer Anastasia Dualla / ... (54 episodes, 2004-2009)
- Donnelly Rhodes ... Dr. Cottle / ... (36 episodes, 2004-2009)
- Nicki Clyne ... Crewman Specialist Cally Henderson / ... (36 episodes, 2004-2008)
- Bodie Olmos ... Lt. Brendan 'Hot Dog' Constanza / ... (36 episodes, 2004-2009)
- Michael Trucco ... Samuel Anders / ... (35 episodes, 2005-2009)
- Leah Cairns ... Racetrack / ... (33 episodes, 2005-2009)
- Rekha Sharma ... Tory Foster (31 episodes, 2006-2009)
- Paul Campbell ... Billy Keikeya (25 episodes, 2004-2006)
- Kate Vernon ... Ellen Tigh (23 episodes, 2004-2009)
- Richard Hatch ... Tom Zarek (22 episodes, 2004-2009)
- Jen Halley ... Ensign Diana 'Hardball' Seelix / ... (21 episodes, 2005-2009)
- Callum Keith Rennie ... Leoben Conoy (20 episodes, 2004-2009)
- Brad Dryborough ... Lt. Louis Hoshi / ... (19 episodes, 2006-2009)
- Matthew Bennett ... Aaron Doral (18 episodes, 2004-2009)
- Luciana Carro ... Louanne 'Kat' Katraine / ... (18 episodes, 2004-2006)
- Lucy Lawless ... D'Anna Biers (16 episodes, 2005-2009)
- Dean Stockwell ... John Cavil (14 episodes, 2006-2009)
- Colin Lawrence ... Lt. Hamish 'Skulls' McCall / ... (13 episodes, 2006-2009)
- Colin Corrigan ... Marine Allan Nowart (12 episodes, 2007-2009)
- Sam Witwer ... Crashdown (11 episodes, 2004-2005)
- Kerry Norton ... Medic Layne Ishay / ... (10 episodes, 2005-2009)
- Christina Schild ... Playa Palacios / ... (10 episodes, 2004-2009)
- Lara Gilchrist ... Paulla Schaffer (10 episodes, 2008-2009)
- Dominic Zamprogna ... Jammer / ... (10 episodes, 2004-2006)
- Tiffany Lyndall-Knight ... The Hybrid / ... (10 episodes, 2006-2009)
- Sebastian Spence ... Lt. Noel 'Narcho' Allison / ... (9 episodes, 2005-2009)
- Keegan Connor Tracy ... Jeanne (9 episodes, 2007-2009)
- Don Thompson ... Specialist 3rd Class Anthony Figurski / ... (9 episodes, 2005-2009)
- Lorena Gale ... Elosha (8 episodes, 2004-2008)
- Rick Worthy ... Simon (8 episodes, 2005-2009)
- Alonso Oyarzun ... Crewman Specialist Socinus / ... (8 episodes, 2004-2005)
- Alisen Down ... Jean Barolay / ... (8 episodes, 2006-2008)
- Biski Gugushe ... Sekou Hamilton / ... (8 episodes, 2004-2009)
- Ty Olsson ... Captain Aaron Kelly / ... (8 episodes, 2005-2009)
- Ryan Robbins ... Charlie Connor / ... (7 episodes, 2006-2009)
- Eileen Pedde ... Sgt. Erin Mathias / ... (7 episodes, 2006-2008)
- Andrew McIlroy ... Jacob Cantrell (7 episodes, 2008-2009)
- Judith Maxie ... Picon Delegate (7 episodes, 2008-2009)
- Mark Sheppard ... Romo Lampkin (6 episodes, 2007-2009)
- Leela Savasta ... Tracey Anne (6 episodes, 2008-2009)
- Iris Paluly ... Speaking Delegate #2 / ... (6 episodes, 2008-2009)
- Marilyn Norry ... Reza Chronides (6 episodes, 2008-2009)
- Alexandra Thomas ... Hera Agathon (6 episodes, 2008-2009)
- Ryan McDonell ... Lt. Eammon 'Gonzo' Pike / ... (6 episodes, 2006-2008)
- Christian Tessier ... Tucker 'Duck' Clellan / ... (5 episodes, 2005-2006)
- Vincent Gale ... Chief Peter Laird (5 episodes, 2005-2009)
- Donna Soares ... Speaking Delegate #1 / ... (5 episodes, 2008-2009)
- Darcy Laurie ... Dealino (5 episodes, 2009)
- Finn R. Devitt ... Nicky Tyrol (5 episodes, 2008-2009)
- Madeleine Parker ... Kacey (5 episodes, 2006)
- Leo Li Chiang ... Tattooed pilot / ... (5 episodes, 2008-2009)
- Graham Beckel ... Colonel Jack Fisk / ... (4 episodes, 2005-2006)
- Chris Shields ... Cpl. Venner (4 episodes, 2005)
- Patricia Idlette ... Sarah Porter (4 episodes, 2005-2006)
- Erica Cerra ... Maya (4 episodes, 2006)
- Iliana Gomez-Martinez ... Hera Agathon (4 episodes, 2009)
- Aleks Paunovic ... Marine Sgt. Fischer / ... (4 episodes, 2005-2007)
- Heather Doerksen ... Sgt. Brandy Harder (4 episodes, 2005-2008)
- Veena Sood ... Quorum Delegate (4 episodes, 2008-2009)
- Mike Dopud ... Crewman Specialist Gage / ... (4 episodes, 2005-2009)
- Derek Delost ... Crewman Specialist Vireem / ... (4 episodes, 2005-2009)
- Michelle Forbes ... Admiral Helena Cain (3 episodes, 2005-2006)
- Malcolm Stewart ... Marshall Bagot (3 episodes, 2005)
- David Kaye ... James McManus (3 episodes, 2005-2006)
- Diego Diablo Del Mar ... Hillard (3 episodes, 2006-2007)
- P.J. Prinsloo ... Lt. Mei 'Freaker' Firelli (3 episodes, 2005-2006)
- Susan Hogan ... Captain Doyle Franks (3 episodes, 2007-2009)
- Sonja Bennett ... Specialist 2nd Class Marcie Brasko (3 episodes, 2008-2009)
- Alison Matthews ... Karen Fallbrook (3 episodes, 2007)
- Stephen Holmes ... Reporter #1 / ... (3 episodes, 2007)
- Curtis Ricks ... Marine Sergeant / ... (3 episodes, 2004-2005)
- William Samples ... Judge #2 / ... (3 episodes, 2007-2009)
- Tobias Mehler ... Zak Adama (3 episodes, 2004-2009)
- Lee Jeffery ... Lt. Paolo 'Redwing' McKay (3 episodes, 2008)
- David Patrick Green ... Xeno Fenner (2 episodes, 2007-2009)
- Roark Critchlow ... Slick (2 episodes, 2009)
- Eric Breker ... Chu / ... (2 episodes, 2004-2006)
- James Remar ... Meier (2 episodes, 2005)
- Jill Teed ... Sgt. Hadrian (2 episodes, 2004)
- Chelah Horsdal ... Didi Cassidy (2 episodes, 2007)
- G. Patrick Currie ... Enzo (2 episodes, 2006-2009)
- John Pyper-Ferguson ... Captain Cole 'Stinger' Taylor / ... (2 episodes, 2005-2006)
- Kurt Evans ... Paramedic Howard Kim / ... (2 episodes, 2005)
- Cailin Stadnyk ... Ensign Davis (2 episodes, 2005)
- Tamara Lashley ... Sue-Shaun (2 episodes, 2005)
- Erika-Shaye Gair ... Young Kara (2 episodes, 2007-2009)