- Samuel Johnson 1754–1763
- Myles Cooper 1763–1775
- Benjamin Moore 1775–1776 acting, 1801–1810
- George Clinton 1784–1787 Chancellor (Regents government); 1st Governor of New York and later 4th Vice President of the United States
- William Samuel Johnson 1787–1800 signed the Constitution of the United States; served as United States Senator from Connecticut
- Charles Henry Wharton 1801–1801
- William Harris 1811–1829 shared authority with Provost John Mitchell Mason until 1816
- William Alexander Due 1829–1842
- Nathaniel Fish Moore 1842–1849
- Charles King 1849–1863 presided over move to Madison Avenue campus
- Frederick Augustus Porter Barnard 1864–1888
- Henry Drisler 1867, 1888–1889 acting
- Seth Low 1890–1901 presided over move to Morningside Heights campus
- John Howard Van Amringe 1899 acting
- Nicholas Murray Butler 1902–1945 Nobel Peace Prize laureate
- Frank D. Fackenthal 1945–1948 acting
- Dwight D. Eisenhower 1948–1953 on leave while Supreme Allied Commander of NATO, later 34th President of the United States
- Grayson L. Kirk 1953–1968 resigned after 1968 protests
- Andrew W. Cordier 1969–1970
- William J. McGill 1970–1980
- Michael I. Sovern 1980–1993
- George Erik Rupp 1993–2002
- Lee C. Bollinger 2002–2023 presided over construction of Manhattanville campus
- Minouche Shafik, Baroness Shafik 2023–Present
https://en.wikipedia.org/wiki/President_of_Columbia_University