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Tags: Polycystic Kidney Disease, kidney failure, renal failure
Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which abnormal cysts develop and grow in the kidneys. Cystic disorders can express themselves at any point, infancy, childhood, or adulthood. The disease occurs in humans and some other animals. PKD is characterized by the presence of multiple cysts (hence, "polycystic") typically in both kidneys; however, 17% of cases initially present with observable disease in one kidney, with most cases progressing to bilateral disease in adulthood.
Polycystic kidney disease is one of the most common hereditary diseases in the United States, affecting more than 600,000 people. It is the fourth leading cause of kidney failure. It causes about 5% of all kidney failure. It is the cause of nearly 10% of end-stage renal disease and affects men, women, and all races equally.
Cause: Polycystic kidney disease is a general term for the two types of PKD, each having their own pathology and causes. The two types of PKD are autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD), which differ in their mode of genetic inheritance.
Prognosis ADPKD individuals might have a normal life; conversely, ARPKD can cause kidney dysfunction and can lead to kidney failure by the age of 40-60. ADPKD1 and ADPKD2 are very different, in that ADPKD2 is much milder.[14] Currently, there are no therapies proven effective to prevent the progression polycystic kidney disease (autosomal dominant).
Famous People with Kidney Disease:
- Childhood Kidney Support Network - Well-known people who have battled Kidney Disease
- Famous People with Kidney Disease
- Ranker - Famous People Who Died of Renal Failure
Further reading
- Wikipedia - Polycystic Kidney Disease
- NIH - Polycystic Kidney Disease
- National Kidney Foundation - Polycystic Kidney Disease
- Chapin, Hannah C.; Caplan, Michael J. (2010-11-15). "The cell biology of polycystic kidney disease". The Journal of Cell Biology. 191 (4): 701–710. doi:10.1083/jcb.201006173. ISSN 0021-9525. PMC 2983067. PMID 21079243.
- Harris, Peter C.; Torres, Vicente E. (2009-01-01). "Polycystic Kidney Disease". Annual Review of Medicine. 60: 321–337. doi:10.1146/annurev.med.60.101707.125712. ISSN 0066-4219. PMC 2834200. PMID 18947299.
- Press, Dove. "Polycystic kidney disease: inheritance, pathophysiology, prognosis, an | IJNRD". www.dovepress.com. Retrieved 2015-08-01.
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