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The professional American football team now known as the Los Angeles Rams played in St. Louis, Missouri as the St. Louis Rams from the 1995 through the 2015 seasons. The Rams relocated from Los Angeles, California to St. Louis in 1995, which had been without a National Football League (NFL) team since the Cardinals moved to Arizona in 1988. The Rams' first home game in St. Louis was at Busch Memorial Stadium against the New Orleans Saints on September 10, 1995 before the Trans World Dome (now known as the Edward Jones Dome) was completed for their November 12 game against the Carolina Panthers. Their last game played at the Edward Jones Dome in St. Louis was against the Tampa Bay Buccaneers on December 17, 2015. The Rams' last game as the St. Louis Rams was on January 3, 2016 against the San Francisco 49ers at Levi's Stadium, where they lost in overtime 19-16.
For more on the history of the St. Louis Rams, see the Wikipedia Article, History of the St. Louis Rams.