Variations: Nissanov, Nissanoff, Nisanof, Nissanof, Nisanoff, Nisanof
It means the 'son of Nisson'. Nisson is a Hebrew name usually given to males born in the month of Nisson according to the Hebrew calendar.
Several distinct families carry this name.
One such family is known to have come from Khatyrchi, Uzbekistan although they may have moved there from Bukhara. This family has a long tradition of Torah Scholars and Rabbis.