The Minsk Ghetto was created soon after the German invasion of the Soviet Union. It was one of the largest in Eastern Europe, and the largest in the German-occupied territory of the Soviet Union. It housed close to 100,000 Jews, most of whom perished in The Holocaust.

The ghetto was created soon after the German invasion of the Soviet Union and capture of the city of Minsk, capital of the Belorussian SSR, on 28 June 1941.

On the fifth day after the occupation, 2,000 Jewish intelligentsia were massacred by the Germans; from then on, murders of Jews became a common occurrence. About 20,000 Jews were murdered within the first few months of the German occupation, mostly by the Einsatsgruppen squads.

Between November 1941 and October 1942, the German government deported nearly 24,000 Jews from Germany, Austria, and the Protectorate of Bohemia and Moravia to Minsk.

The ghetto was liquidated on 21 October 1943, with many Minsk Jews perishing in the Sobibor extermination camp.

Several thousands were massacred at Maly Trostenets extermination camp (before the war, Maly Trostenets was a village a few miles to the east of Minsk). By the time the Red Army retook the city on 3 July 1944, there were only a few Jewish survivors.

• האנציקלופדיה של הגטאות, יד ושם

El Male Rachamim Holocaust Prayer