I am passing along a comment from Brian Blitz for those who are not following the Czech Jewish Genealogy Facebook group:
"I compared the contents of former Fond 241 and its Vademecum equivalent at the end of May 2021. The inventory numbers match up until item 70 (Citoliby). Where indicated, there is some new content. When items were moved across, those items which had a letter in badatelna (e.g., inv.c 458a) were put in sequential order. Some inventory numbers in vademecum are skipped. There are also a few items which were in badatelna and not in vademecum.
71: CIVOV (p. Melnik) O 1846, N 1835-1848, Z 1834-1847
131: Doksany (o. Litomerice)
138: Dolni Jiretin (o. Most)
181: Horni Brusnice (o. Trutnov)
183: Horni Litvinov (o. Most)
333: skipped
337: Kostelec Nad Labem Z 1866-1890
342: skipped
346: Kosetice N 1845-1868
347: Kosetice O 1845-1859
348: Kosetice Z 1845-1869
355: skipped
386: skipped
403: skipped
451-456: skipped
470: skipped
480: Fond 241 inv 458a Nachod N 1840-1860 renumbered to 480
481: Fond 241 inv 458b Nachod Z 1839-1860 renumbered to 481
508: skipped
519: Fond 241 inv 494a Nymburk Z 1845, 1846, 1860-61 renumbered 519
533: skipped. This lines up with Opocno 508 O 1849, 1858, N 1842-1868, Z 1844-1866, which is not on Vademecum
611-613: skipped
Praha 6 – Strahov (241, inv. 598) N, 1850, 154, 1857, O, Z 1851, 1858 is not on Vademecum
643: Omitted
685: Former 241 659a Rudne N 1842-1852, O 1849-1850, Z 1846-1864
731: Fond 241 Inv 704a Stanovice N 1863, 1865, O, Z renumbered
734: Former 241 706a Stare Hobzi N 1847-1873
Stare Hobzi O 1849-1872 (Former 241 706b); Stare Hobzi Z 1847-1873 (Former 241 706c) not on Vademecum
735 – 736: skipped
741: skipped
780: skipped
813: skipped
824: skipped
827: skipped
901: skipped
923: skipped
930: skipped
943: Former 241 903a Zdechovice N 1840-1883, O 1842, Z 1843-1858 renumbered
945: Zemechy O, N 1848-1855, Z 1837 (there are two vademecum inv 945s, but no 946)
946: skipped
1018, 1019: skipped
Novy Jicin N 1847-1870 not on Vademecum"