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Safiye Hanımsultan (1562 - ?): Ismihan Sultan's eldest child. She was firstly married to her father's cousin Sokollu Mustafa Pasha, governor of Buda. After his execution in 1578, she married the new governor of Buda, Silahdar Cafer Pasha. After his death in 1587, she gave birth to their twin sons, Mehmed Bey and Cafer Bey, who died as children. She married thirdly to Sultanzade Abdülbaki Bey, son of her mother's cousin Hümaşah Sultan.
1st Marriage to cousin of her father Sokollu Mustafa Pasha, who was governor of Buda
2nd Marriage to Silahdar Cafer Pasha and had two sons (twins) Mehmed Bey and Cafer Bey, who died as children.
3rd Marriage to Sultanzade Abdülbaki Bey, son of her mother's cousin Hümaşah Sultan.
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1562
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