I am back in this family, trying to resolve some potential confusion.
There is a man called Wolf Slawes d. 1630 Prague who is pretty important for us to figure out.
Here is his profile on Geni.
Rabbi Benjamin Wolf Spira
One source, which I added just this week, are personal letters from Wolf and his wife Chava written in 1619 that were found (undelivered, apparently) and published in 1911. Jüdische Privatbriefe aus dem Jahre 1619 (Landau & Wachstein). See https://www.geni.com/documents/view?doc_id=6000000078559969717
Another source is an article published by Ludwig Lazarus in 1912, Nueue Beiträge zur Geschichte der Familie Fränkel-Spira, which includes a 1734 letter from Samuel Porges to the head of the community Samuel b. Wolf Fränkels Spira about their common family background. See https://www.geni.com/documents/view?doc_id=6000000120835939887
According to the Porges letter Michel b. Simon Spira had three sons: (1) Wolf (called Slawes after his wife) d. 1630, father of Rabbi Aharon Simon Spira. (2) Rabbi Chaim of Posen, and (3) Rabbi Man of Brisk.
In the Privatbriefe we find a letter (#9, page 28-29) from Wolf Slawes to his in-law Jekel Schick in Vienna, who is Moses Jacob "Jekel" Schick. I have made the wives of Wolf and Jekel into sisters, but I don't yet have proof of that, although it makes sense from the context of the 1619 letter.
In any case, there is a family relationship between this Wolf Slawes in Prague and Jekel Schick in Vienna.
Now take a look at this Wolf who is called Heller Slavis-Segal. Rabbi Benjamin Wolf Spira
This Wolf Heller Slawes is married to Nissel, the daughter of Tosafot Yomtov Lipman Heller.
In Hock-Kaufman her grave inscription is described as
240 Nissel e' r' Wolf Slawes bto shel haGaon byl Tosafot JomTov 1639/40
Note that Wolf does not have a SeGal on her insccription so he may not be a Levi.
There is a grandson of Wolf Slawes Horowitz who dies in Prague in 1700 and his inscription is
240 habachur Juda [bn Manes seGal] neched hajashish Wolf Slawes Horwitz seGal 1700/01
Right now we have a son of Wolf and Nissel listed as Nathan Halevi Heller SeGal. Rabbi Nathan Flekeles Horowitz
Nathan and his wife Chana Katzenellenbogen have a daughter Nissel d. 1689 Prague married to Shmuel Schick. Nissel's grave inscription says
240 Nissel nechda shel r' Wolf Slawes ?Flekeles? 1689/90
Samuel Schick dies in Pruzany, Belarus. His father is listed on Geni as Menachem Schick, recently added, no source, and a wife named Heller, daughter of Moshe Halevi and sister of Meshulem Feivish and Avraham Heller.
I am very suspicious of the idea that there are two Wolf Slawes in Prague. Should be the same person. He may not be a Levi, so no SeGal. He is connected perhaps to Horowitz and/or Flekeles, perhaps through his wife's mother, who could be the original Slawe? His wife Chawa, who is alive in 1619, may not be his only wife. Although someone added a death date for her, I haven't found a source for that. Chawa may have died and Wolf remarried Nisssel, the daughter of Tosafot Jomtov,
I am not sure if the young Nissel is connected, but it looks like she may not be the daughter of Nathan Heller SeGal and Chana Katzenellenbogen. What is the source for that?
And Nissel's husband Shmuel Schick should probably be from the Prague Schick family, perhaps closely related to her grandfather Wolf's in-law Jekel.
Anyone have any thoughts? I want to move this around and play with it. Hatte Rubenstein Blejer last time you objected, but I really think we need to review and revise this area and not rely solely on the late 19th century sources from before the two publications in 1911-12.