McGuffin is a Scots-Irish subclan of MacFie, which is said to mean "Son of the Dark Faery." Other related subclans and surnames are McGuffy, McDuffy, MacAfee, McCaffrey, Mahaffey, etc. The homeland of the MacFie Clan was the Isle of Colonsay, one of the Inner Hebrides. The Mac/fies were driven from the islands into Galloway (southwestern Scotalnd) then further dispersed into Ireland and North America.